Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Thiamin (vitamin B1) (as thiamine mononitrate)
50 mcg
4,167%
Riboflavin (vitamin B2)
50 mg
3,846%
Niacin (vitamin B3) (as niacinamide)
50 mg
313%
Vitamin B6 (as pyridoxine HCl)
50 mg
2,941%
Folate
666 mcg DFE(400 mcg folic acid)
167%
Vitamin B12 (as cyanocobalamin)
50 mcg
2,083%
Biotin (as D-biotin)
50 mcg
167%
Pantothenic Acid (vitamin B5) (as D-ca pantothenate)
50 mg
1,000%
Choline (as choline bitartrate)
21 mg
4%
Inositol
50 mg
**
Herbal Powdered Blend(kelp [plant] , acerola extract complex [fruit], alfalfa [leaf and stem], parsley [leaf], rose hips [fruit], watercress [herb])
3.5 mg
**
Top Medical Research Studies
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
Most Useful Reviews
9
Relieved back pain
Thanks to this vitamin, I alleviated my back pain and improved liver function. I find it beneficial to supplement this vitamin several times a week.
Read More
9
Excellent results
I was prescribed B vitamins for my husband's liver disease related to Ménière's disease and vascular issues. We chose Solgar for its reputation, despite the higher cost in Russia. He has been taking it once a day for over six months, and the results are excellent! I highly recommend it.
Read More
8
Improved liver function
3 people found this helpful
An excellent balanced composition; I felt the effect on my liver and bile immediately. My eyes cleared up (no yellowness), and I experienced a return to normal sleep as a pleasant side effect. I did not notice such results when taking B1 and B3 separately. I was pleasantly surprised.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieved back pain
Thanks to this vitamin, I alleviated my back pain and improved liver function. I find it beneficial to supplement this vitamin several times a week.
Read More
9
Excellent results
I was prescribed B vitamins for my husband's liver disease related to Ménière's disease and vascular issues. We chose Solgar for its reputation, despite the higher cost in Russia. He has been taking it once a day for over six months, and the results are excellent! I highly recommend it.
Read More
8
Improved liver function
3 people found this helpful
An excellent balanced composition; I felt the effect on my liver and bile immediately. My eyes cleared up (no yellowness), and I experienced a return to normal sleep as a pleasant side effect. I did not notice such results when taking B1 and B3 separately. I was pleasantly surprised.
Read More
7.5
Boosted immunity
Vitamins B-50 are essential for strengthening the immune system and normalising liver function. They help maintain normal blood sugar levels and improve skin, mucous membranes, nails, and hair. They're also good for vision and promote hemoglobin production.
Read More
Frequently Asked Questions
8
Improved liver function
3 people found this helpful
An excellent balanced composition; I felt the effect on my liver and bile immediately. My eyes cleared up (no yellowness), and I experienced a return to normal sleep as a pleasant side effect. I did not notice such results when taking B1 and B3 separately. I was pleasantly surprised.
9
Excellent results
I was prescribed B vitamins for my husband's liver disease related to Ménière's disease and vascular issues. We chose Solgar for its reputation, despite the higher cost in Russia. He has been taking it once a day for over six months, and the results are excellent! I highly recommend it.
9
Relieved back pain
Thanks to this vitamin, I alleviated my back pain and improved liver function. I find it beneficial to supplement this vitamin several times a week.
7.5
Boosted immunity
Vitamins B-50 are essential for strengthening the immune system and normalising liver function. They help maintain normal blood sugar levels and improve skin, mucous membranes, nails, and hair. They're also good for vision and promote hemoglobin production.
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
References
- Ciftel S, Ciftel S, Altuner D, Huseynova G, Yucel N, et al. Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats. BMC Pharmacol Toxicol. 2025;26:67. 10.1186/s40360-025-00901-7
- Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. 10.1038/s41467-024-54826-6
- Zhu J, Liao X, Du L, Lv P, Deng J. Associations of serum folate and vitamin B levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective cohort study. Front Endocrinol (Lausanne). 2024;15:1426103. 10.3389/fendo.2024.1426103
- Shen H, Zhou L, Yang Y, Shu H, Wu D, et al. The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage. Hepatol Commun. 2025;9. 10.1097/HC9.0000000000000599
